Planar-bilayer activities of linear oligoester bolaamphiphiles

• Jonathan K. W. Chui,
• Thomas M. Fyles and
• Horace Luong

Beilstein J. Org. Chem. 2011, 7, 1562–1569, doi:10.3762/bjoc.7.184

• voltage-dependent. The varied and irregular activities were summarized with the aid of a recently developed “activity-grid” method. Keywords: activity grid; single-molecule studies; synthetic ion channels; voltage clamp experiment; Introduction Ion channels modulate conductance in cell membranes, and

• suffers from a need for specialized equipment, as well as the daunting task of making sense of all but the most regular of activities. We have recently developed an empirical classification scheme for summarizing the range of voltage-clamp activities [10]. This “activity grid” represents the conductance

• criteria, and we were unable to visually discern any obvious patterns; for this reason we turned to the summary activity grids as a (potentially) model-independent method for recording diverse behaviors. Preparing the “activity grid” from empirical current–time traces was facilitated by a suite of custom